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KMID : 0861020030180020149
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Korea Journal of Herbology
2003 Volume.18 No. 2 p.149 ~ p.156
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Pharmacological Activities of the Polysaccharide obtained from the Fruit body and Mycelia of Ganoderma lucidum IY005
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이준우/Lee, Jung-Woo
방광웅/서부일/이은숙/Bang, Kwang-Woong/Seo, Bu-Il/Lee, Eun-Sook
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Abstract
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Objectives : To examine pharmacological activity of Ganoderma lucidum IY005 which had been isolated from Kwangneung in Gyeonggi Province and extracted with hot water.
Methods : We studied the pharmacoloical activity of polysaccharide from Ganoderma lucidum IY005. We measured antitumor activity against sarcoma 180 bearing mice, anticomplementary activity, activation of reticuloendothelial system, production of hemolytic plaque forming cell and nitric oxide production.
Results : The tumor inhibition ratio of the polysaccharides obtained from fruit body and liquid cultured mycelia of Cmodenna lucidum IY005 against sarcoma 180 were 64.7% and 55.2%, respectively. And also, it was shown to activate reticuloendothelial system of ICR mice in the carbon clearance test and to increase hemolytic plaque forming cells of the spleen. Raw 264.7 macrophages treated with fruit body and mycelia fraction produced the nitric oxide and tumor necrosis factor-alpha.
Conclusion : These results suggest that polysaccharides obtained from fruit body and mycelia of Ganoderma lucidum IY005 were similar to the immunological activities. And these fractions contain immunoregulatory components
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